Before the XX.th century dentistry was for the most part completely unregulated. Many times monks dealt with dental problems, as they were the only people who understood anything about the human body.
The human oral cavity is home to startling number of different strains of bacteria and microbes, not to mention the enzymes that deal with them. There are also trace amounts of fungus in the mouth, and every once in a while, especially when the immune system is over taxed, these funguses can start to proliferate extensively, and cause a fungal infection in the mouth.
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